Abstract:This paper takes 91 cities'' national high-tech industrial development zones as the research object, measures the Mar effect and Jac effect of their knowledge externalities, and gives the radiation range of knowledge externalities of national high-tech industrial clusters, and quantitatively calculates the knowledge externalities effect on economic growth and technical advancement. The results show that the knowledge spillover effect of the industry in the process of agglomeration of high-tech industries in China is greater, and the Jac externalities of the high-tech industrial clusters in the western region have a more significant positive effect on regional economic growth.